Medical Disclaimer
This article discusses prescription medications and clinical protocols. It is for educational purposes and does not replace personalized medical advice. Talk to Dr. Moleon or your healthcare provider before starting, changing, or stopping any medication.
Book a consultation with Dr. Moleon →
— Body Good Studio Clinical Team
Bottom line: Tirzepatide shows slightly better weight loss results (~22% vs ~15% body weight), but semaglutide is more affordable and has broader insurance coverage. If you're starting GLP-1 treatment for the first time, semaglutide is often the best choice.
Start Semaglutide ($229/mo) → Start Tirzepatide ($299/mo) →
Quick Comparison
| Factor | Semaglutide | Tirzepatide |
|---|---|---|
| Mechanism | GLP-1 agonist | Dual GLP-1 + GIP agonist |
| Average Weight Loss | 15-17% body weight | 20-22% body weight |
| Injection Frequency | Once weekly | Once weekly |
| Best For | First-time GLP-1 users | Experienced users, higher goals |
| Body Good Cost | $229/month | $299/month |
Start Semaglutide Program → Start Tirzepatide Program →
Not sure which one? Take our quiz
Which One Is More Effective?
Tirzepatide is more effective for weight loss based on clinical trial data:
Semaglutide (STEP 1 trial - Wegovy 2.4mg):
- Average weight loss: 14.9% of body weight
- 50% of patients lost ≥15% body weight
- 32% of patients lost ≥20% body weight
Tirzepatide (SURMOUNT-1 trial - Zepbound 15mg):
- Average weight loss: 20.9% of body weight
- 77% of patients lost ≥15% body weight
- 63% of patients lost ≥20% body weight
Real-world example: A patient starting at 200 lbs on semaglutide: Expected loss ~30 lbs → 170 lbs. Same patient on tirzepatide: Expected loss ~42 lbs → 158 lbs.
Start with Semaglutide → Start with Tirzepatide →
Which One Should You Start With?
Start with Semaglutide if:
- You've never tried a GLP-1 medication before
- You want to minimize cost ($229 vs $299/month)
- Your insurance is more likely to cover it
- You have moderate weight loss goals (15-20% body weight)
Consider Starting with Tirzepatide if:
- You have significant weight to lose (50+ lbs or BMI ≥35)
- You've tried semaglutide before and plateaued
- You want the most effective option from day one
- Cost difference isn't a concern ($70/month more)
Can You Switch Between Them?
Yes, switching is safe and common. Body Good makes it easy — no washout period needed.
Most patients start on semaglutide. If you plateau after 6+ months or need better results, we'll transition you to tirzepatide seamlessly.
Ready to Start?
Body Good offers both medications — your physician will recommend the best option for you
Semaglutide
$229/month
Tirzepatide
$299/month
Based on clinical trial data for the referenced FDA-approved medication. Individual results vary. These results do not establish the safety or effectiveness of compounded medications.