Both Wegovy® (Semaglutide) and Zepbound® (Tirzepatide) are once-weekly GLP-1–based injections for weight management—here’s how they stack up for self-pay pricing, coverage, and results.

💎 Self-Pay Branded: Wegovy vs Zepbound

Compare FDA-approved brand medications side by side so you can choose the option that best fits your goals and budget.
Feature Wegovy (Semaglutide) Zepbound (Tirzepatide)
Monthly Cost (Cash Pay) $499/month for all doses via NovoCare Pharmacy $499/month for 7.5 mg or 10 mg vials via LillyDirect
Starter Dose Option Promotional rates may be available for the first prescription fill (varies by NovoCare offer). Some starter vials may be priced around $349 through LillyDirect introductory offers.
How It’s Ordered Direct from NovoCare Pharmacy with home delivery options. Direct through LillyDirect Self-Pay Program with coordinated pharmacy fulfillment.
Medication Type GLP-1 receptor agonist (Semaglutide) Dual GIP + GLP-1 agonist (Tirzepatide) for an enhanced metabolic effect.
Average Weight Loss ~15% body weight over 12–18 months when combined with healthy habits. 20–22% body weight over 12–18 months when combined with healthy habits.
Insurance / Copay Option With insurance coverage, many pay $0–$25/month after copay cards and plan benefits. With insurance coverage, many pay $0–$25/month through Lilly cost-savings programs, depending on eligibility.
Delivery Method Weekly injector pen Weekly injector pen
Best For Patients preferring steady, gradual progress with a single-hormone GLP-1 medication. Zepbound: Patients seeking faster or more pronounced results with dual-hormone (GIP + GLP-1) therapy.
Wegovy (Semaglutide)
Monthly Cost (Cash Pay)
$499/month for all doses via NovoCare Pharmacy
Starter Dose Option
Promotional rates may apply for first fill
How It’s Ordered
Direct from NovoCare Pharmacy (home delivery available)
Medication Type
GLP-1 receptor agonist (Semaglutide)
Average Weight Loss
~15% body weight over 12–18 months
Insurance / Copay Option
With coverage: many pay $0–$25/month
Delivery Method
Weekly injector pen
Best For
Patients preferring steady, gradual progress
Zepbound (Tirzepatide)
Monthly Cost (Cash Pay)
$499/month for 7.5 mg or 10 mg vials via LillyDirect
Starter Dose Option
Some starter vials priced around $349
How It’s Ordered
Direct through LillyDirect Self-Pay Program
Medication Type
Dual GIP + GLP-1 agonist (Tirzepatide)
Average Weight Loss
20–22% body weight over 12–18 months
Insurance / Copay Option
With coverage: many pay $0–$25/month
Delivery Method
Weekly injector pen
Best For
Patients seeking faster or more pronounced results

*Information on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always talk to your licensed healthcare provider about which option is right for you.

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Programs Most Popular Fastest Semaglutide Subscription Adaptable
GLP Elite

Flexible weight loss to accelerate and maintain your GLP-1 results.

RM3

The quickest way to safely lose weight and sustain it for life.

DirectMed

GLP-1 Subscription; Our auto-ship program delivers GLP-1s to your door every month for convenient, hassle-free weight loss.

Lifestyle

A-la-carte program to match your lifestyle with moderate weight loss and maintenance.

Patented medication included
Weekly fat burner boosters included
Consultation with medical provider

Top 5 FAQs

1. How does the self-pay option work?

Both Wegovy and Zepbound now offer direct cash-pay programs through their manufacturers — no insurance required. You pay a flat monthly price, and the medication ships directly from the manufacturer’s pharmacy partner.

2. Are these the same as the compounded versions?

No. These are brand-name, FDA-approved medications from Novo Nordisk and Eli Lilly (Zepbound). Compounded versions are custom-formulated alternatives prepared by licensed pharmacies, but they are not FDA-approved.

3. Can I use insurance later if my plan changes?

Yes. If your insurance begins covering GLP-1 medications, you can switch from self-pay to insurance billing at any time, if eligible. Your provider or pharmacy can help with that transition. Coverage and copays will always depend on your specific plan and benefits.

4. Which medication works faster?

Both are effective, but Zepbound (tirzepatide) has been shown in clinical trials to produce greater average weight loss for many patients. Wegovy (semaglutide) tends to have a gentler onset and may be a better fit for some first-time users. Your Body Good provider will help you choose based on your health history and goals.

5. What’s included in the Body Good self-pay branded program?

Your $49 program fee covers your medical consultation and prescription management through Body Good’s telehealth platform. Medications are not included in this fee—you’ll pay the manufacturer’s pharmacy directly (Wegovy via NovoCare, Zepbound via LillyDirect) at their current self-pay prices.