💊 Semaglutide vs. Tirzepatide Comparison

Feature Semaglutide Tirzepatide
Brand Names Wegovy®, Ozempic® (compounded versions available) Zepbound®, Mounjaro® (compounded versions available)
Mechanism GLP-1 receptor agonist (mimics natural hormone that regulates appetite and blood sugar) Dual GLP + GLP-1 receptor agonist (targets two hormones for stronger effect)
Effectiveness Average 15% body weight reduction over 12–18 months Average 20–22% body weight reduction over 12–18 months
Appetite Control Strong appetite suppression More potent appetite suppression and energy balance
Onset of Results Noticeable within 4–6 weeks Often noticeable within 2–4 weeks
Dosing Frequency Weekly injection Weekly injection
Common Side Effects Nausea, constipation, diarrhea, fatigue Similar side effects; may be slightly stronger early on
Best For First-time GLP-1 users or those preferring gradual titration Patients needing faster results or who’ve plateaued on Semaglutide
Semaglutide
Brand Names
Wegovy®, Ozempic® (compounded versions available)
Mechanism
GLP-1 receptor agonist (mimics natural hormone that regulates appetite and blood sugar)
Effectiveness
Average 15% body weight reduction over 12–18 months
Appetite Control
Strong appetite suppression
Onset of Results
Noticeable within 4–6 weeks
Dosing Frequency
Weekly injection
Common Side Effects
Nausea, constipation, diarrhea, fatigue
Best For
First-time GLP-1 users or those preferring gradual titration
Tirzepatide
Brand Names
Zepbound®, Mounjaro® (compounded versions available)
Mechanism
Dual GLP + GLP-1 receptor agonist (targets two hormones for stronger effect)
Effectiveness
Average 20–22% body weight reduction over 12–18 months
Appetite Control
More potent appetite suppression and energy balance
Onset of Results
Often noticeable within 2–4 weeks
Dosing Frequency
Weekly injection
Common Side Effects
Similar side effects; may be slightly stronger early on
Best For
Patients needing faster results or who’ve plateaued on Semaglutide
×
Programs Most Popular Fastest Semaglutide Subscription Adaptable
GLP Elite

Flexible weight loss to accelerate and maintain your GLP-1 results.

RM3

The quickest way to safely lose weight and sustain it for life.

DirectMed

GLP-1 Subscription; Our auto-ship program delivers GLP-1s to your door every month for convenient, hassle-free weight loss.

Lifestyle

A-la-carte program to match your lifestyle with moderate weight loss and maintenance.

Patented medication included
Weekly fat burner boosters included
Consultation with medical provider

Top 5 FAQs

1. How does the Insurance Program work?

Our insurance program starts with a $75 membership fee that covers your consultation and prior authorization submission.

Your provider determines if you qualify medically, then we handle the insurance process.

If approved, you’ll typically pay around $25 at your local pharmacy for the medication. If denied, you can easily switch to our self-pay compounded or branded options to start right away.

2. What’s the main difference between Semaglutide and Tirzepatide?

Both are powerful GLP-1 medications that help with weight loss and appetite control. Semaglutide targets one hormone (GLP-1), while Tirzepatide targets two (GIP + GLP-1), offering a stronger metabolic effect and faster results for many patients.

Your provider will recommend which is best based on your goals, tolerance, and medical history.

3. What side effects should I expect?

The most common side effects include:

  • Mild nausea or upset stomach
  • Diarrhea or constipation
  • Fatigue or headache

These usually improve as your body adjusts. Rare risks include pancreatitis, gallbladder issues, or allergic reactions. You’ll be closely monitored by your provider to minimize any issues.

4. Are compounded versions safe?

Yes — our compounded Semaglutide and Tirzepatide are prepared by licensed U.S. compounding pharmacies that meet strict quality standards.

However, compounded medications are not FDA-approved, as they are custom formulations created for individual patients when commercial products are unavailable or cost-prohibitive.

5. Can I switch between Semaglutide and Tirzepatide later?

Absolutely. If you start with Semaglutide and later want to try Tirzepatide (or vice versa), your provider can safely guide the transition.

Some patients begin with Semaglutide to ease in, then switch to Tirzepatide once their body adjusts or if they hit a weight-loss plateau.