💊 Semaglutide vs. Tirzepatide Comparison

Feature Semaglutide Tirzepatide
Brand Names Wegovy®, Ozempic® (FDA-approved branded prescription medications) Zepbound®, Mounjaro® (FDA-approved branded prescription medications)
Mechanism GLP-1 receptor agonist (mimics natural hormone that regulates appetite and blood sugar) Dual GLP + GLP-1 receptor agonist (targets two hormones for stronger effect)
Effectiveness Average 15% body weight reduction over 12–18 months Average 20–22% body weight reduction over 12–18 months
Appetite Control Strong appetite suppression More potent appetite suppression and energy balance
Onset of Results Some patients may notice changes within 4–6 weeks; results vary. Some patients may notice changes within 2–4 weeks; results vary.
Dosing Frequency Weekly injection Weekly injection
Common Side Effects Nausea, constipation, diarrhea, fatigue Similar side effects; may be slightly stronger early on
Best For First-time GLP-1 users or those preferring gradual titration Patients needing faster results or who’ve plateaued on Semaglutide
Semaglutide
Brand Names
Wegovy®, Ozempic® (FDA-approved branded prescription medications)
Mechanism
GLP-1 receptor agonist (mimics natural hormone that regulates appetite and blood sugar)
Effectiveness
Average 15% body weight reduction over 12–18 months
Appetite Control
Strong appetite suppression
Onset of Results
Some patients may notice changes within 4–6 weeks; results vary.
Dosing Frequency
Weekly injection
Common Side Effects
Nausea, constipation, diarrhea, fatigue
Best For
First-time GLP-1 users or those preferring gradual titration
Tirzepatide
Brand Names
Zepbound®, Mounjaro® (FDA-approved branded prescription medications)
Mechanism
Dual GLP + GLP-1 receptor agonist (targets two hormones for stronger effect)
Effectiveness
Average 20–22% body weight reduction over 12–18 months
Appetite Control
More potent appetite suppression and energy balance
Onset of Results
Some patients may notice changes within 2–4 weeks; results vary.
Dosing Frequency
Weekly injection
Common Side Effects
Similar side effects; may be slightly stronger early on
Best For
Patients needing faster results or who’ve plateaued on Semaglutide

Information above is for educational purposes only and is based on published data for FDA-approved branded medications, not compounded products. Compounded medications are not FDA-approved, and individual results vary.

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Programs Most Popular Fastest Semaglutide Subscription Adaptable
GLP Elite

Flexible weight loss to accelerate and maintain your GLP-1 results.

RM3

The quickest way to safely lose weight and sustain it for life.

DirectMed

GLP-1 Subscription; Our auto-ship program delivers GLP-1s to your door every month for convenient, hassle-free weight loss.

Lifestyle

A-la-carte program to match your lifestyle with moderate weight loss and maintenance.

Patented medication included
Weekly fat burner boosters included
Consultation with medical provider

Top 5 FAQs

1. How does the Insurance Program work?

Our insurance program starts with a $75 membership fee that covers your consultation and prior authorization submission.

Your provider determines if you qualify medically, then we handle the insurance process.

If approved, many patients pay around $25 at their local pharmacy for the medication, depending on their insurance plan. If coverage is not approved, your provider can discuss self-pay options, which may include compounded or branded medications when clinically appropriate.

2. What’s the main difference between Semaglutide and Tirzepatide?

Both are powerful GLP-1 medications that help with weight loss and appetite control. Semaglutide targets one hormone (GLP-1), while Tirzepatide targets two (GIP + GLP-1), offering a stronger metabolic effect and faster results for many patients.

Your provider will recommend which is best based on your goals, tolerance, and medical history.

3. What side effects should I expect?

The most common side effects include:

  • Mild nausea or upset stomach
  • Diarrhea or constipation
  • Fatigue or headache

These usually improve as your body adjusts. Rare risks include pancreatitis, gallbladder issues, or allergic reactions. You’ll be closely monitored by your provider to minimize any issues.

4. Are compounded versions safe?

Yes — when appropriate, compounded semaglutide and tirzepatide prescriptions are prepared by licensed U.S. compounding pharmacies that meet strict quality standards.

However, compounded medications are not FDA-approved and do not undergo FDA review for safety, efficacy, or quality. They are custom formulations created for individual patients when an FDA-approved alternative is not appropriate, as determined by a licensed provider.

5. Can I switch between Semaglutide and Tirzepatide later?

It may be possible to switch between semaglutide and tirzepatide, but this decision is always made by your prescribing provider.

Your provider will consider your response to treatment, side effects, medical history, and goals before recommending any change in medication.